Can designing with living systems be the change we need in the context of today’s current environmental and ecological challenges? This Design Museum symposium seeks answers to that question, with help from Brenda Parker and Marcos Cruz, co-directors of Bio-Integrated Design / Bio-ID; textile futures expert Carole Collet; and Helene Steiner, co-founder of startup incubator Open Cell. In the context of climate change and mass extinction, the symposium argues that design can be a powerful agent for change in building an alternative sustainable model. When collaborating with living organisms such as algae, mycelium and microbes, designers are exploring new ways to shape and form our material world in ways that are respectful of our planetary boundaries.